Drug Safety Update

Filters should be used during the administration of Parenteral Nutrition for patients in all care settings

Issued 2 Sep 2026

Read and act on the official notice on GOV.UK

In plain English, for the pharmacy team

Why is this relevant to community pharmacy

Parenteral nutrition is a feed given directly into the bloodstream. This notice matters because using it without a filter has been linked to serious harm, including one death. It affects pharmacists and pharmacy staff who supply, prepare, dispense, or support home use of parenteral nutrition.

What to tell patients

Use your professional judgement for each patient.

  • Filters should be used when parenteral nutrition is given, to help stop unwanted particles entering the bloodstream.
  • An integrated filter may already be part of the giving set. If not, an add-on filter will be needed.
  • If you or your family member give parenteral nutrition at home and an add-on filter is needed, you should be given the right training.
  • Speak to your healthcare professional if you have concerns about the use of filters with your parenteral nutrition.
  • Report suspected side effects to parenteral nutrition on a Yellow Card.

What needs to be done

  • Make sure any parenteral nutrition supplied or supported by the pharmacy is given with a filter with a pore size no larger than 1.2 micrometres.
  • If the parenteral nutrition is aqueous or lipid-free, use a 0.2 micrometre filter where available.
  • Pharmacists: check that local procedures for parenteral nutrition mention filter use as standard practice.
  • Pharmacists: if the pharmacy supports home parenteral nutrition, make sure patients and carers are trained if integrated filters are not provided.
  • Report suspected adverse reactions to parenteral nutrition on a Yellow Card.
  • Read and act on the official GOV.UK notice.

Pharmshark summary, checked and approved by Chris Dotchin on 2 Nov 2026. It is not the official notice: always read and act on the GOV.UK notice.

How this summary was written

An AI tool drafted it from the MHRA's own notice and nothing else. A second check compared every line with the notice. Pharmshark's clinical lead then read it against the notice, edited it where needed and approved it. If the MHRA changes the notice, this summary is taken down until it has been checked again.

The MHRA's summary

Administration of parenteral nutrition without a filter has been associated with a number of adverse incidents including an embolism which resulted in a fatal outcome.

MHRA's audience tags: Anaesthesia intensive care, Cancer, Care home staff, Critical care, Emergency medicine, General practice, General surgery, Gi hepatology pancreatic disorders, Haematology, Nutrition dietetics, Paediatrics neonatology, Pain management palliation, Pharmacy

Pharmshark is not an official alerting route. Make sure your pharmacy receives alerts directly from the MHRA and through your organisation, and always act on the official GOV.UK notice.

Source: the MHRA on GOV.UK. Contains public sector information licensed under the Open Government Licence v3.0. Pharmshark is not affiliated with or endorsed by the MHRA.